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MSU researchers use newborn blood data to study cerebral palsy

Posted on August 31st 2009

(Michigan State University) A statewide team of researchers led by a Michigan State University epidemiologist are hoping Michigan’s archive of newborn blood spots will help them uncover the causes of cerebral palsy, the most common disabling motor disorder in children with annual health costs of $12 billion. (Source: EurekAlert! – Social and Behavioral Science)



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Treating complex movement disorders in children with cerebral palsy.

Posted on August 31st 2009

Authors: Lundy C, Lumsden D, Fairhurst C

PMID: 19907680 [PubMed - in process] (Source: The Ulster Medical Journal)



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Cerebral palsy following neonatal hypoxic seizures in singleton term infants: the influence of parity.

Posted on August 31st 2009

Authors: Mahony R, Enright F, O’Herlihy C, Foley ME
This was a retrospective review of term singleton neonates (> 37 weeks) with early onset seizures, with and without encephalopathy, from 1989 through 2000. Our aim was to examine the relationship between antepartum and intrapartum obstetric events, neonatal hypoxic seizures and subsequent neurological impairment of 77,838 infants, the incidence of seizures was significantly higher among primiparas (2.4/1000; 67/31,729) compared with multiparas (0.35/1000; 16/46,109)(p < 0.001). Compared with multiparas, seizures with encephalopathy occurred more frequently among primiparas (0.8/1000; 26/31,729) vs. multiparas (0.2/1000; 8/46,109), were more commonly associated with unexplained intrapartum hypoxia (0.6/1000, n = 20 vs.0.04/ 1000,…



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Comparison of digito-palmar dermatoglyphic traits in children with cerebral palsy and their close family members.

Posted on August 31st 2009

Authors: Polovina-Proloscić T, Milicić J, Cvjeticanin M, Polovina A, Polovina S
Cerebral palsy is one of the main causes of severe disability in children. Sixty children (30 boys and 30 girls) were included in the study. Quantitative digito-palmar dermatoglyphic traits were analyzed. Prints of digito-palmar dermatoglyphs obtained from the children’s parents (60 mothers and 60 fathers) and from 400 phenotypically healthy adults from the Zagreb ware used as control groups. Analysis of quantitative dermatoglyphic traits of the digito-palmar complex revealed statistically significant differences in a number of variables between the fathers and their children suffering from cerebral palsy (TRC 180.3 > 158.6), with a greater number of variables involved in male children with c…



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Commentary

Posted on August 31st 2009

In their article, Sutphin et al seek to examine the development of antibodies to a specific formulation of botulinum toxin type A (Botox, Allergan, Irvine, CA) with a seemingly simple and straightforward experiment. The question of antibody formation in response to BTA is obviously of greater import in the functional world of medicine as opposed to the aesthetic world. When treating cervical dystonia or cerebral palsy spasm, doses are much higher, intervals are frequently shorter, and the consequences of losing your best treatment option are much greater than when treating an aesthetic patient. However, loss of the toxin as a cosmetic treatment is obviously something we would rather avoid, however rare those cases might be. (Source: Aesthetic Surgery Journal)



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