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Letter to the editor on ‘Safety of botulinum toxin type A among children with spasticity secondary to cerebral palsy: a systematic review of randomized clinical trials’.

Posted on August 30th 2009

Authors: Idrovo AJ, Albavera-Hernández C, Rodríguez JM

PMID: 19713401 [PubMed - in process] (Source: Clinical Rehabilitation)

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United Cerebral Palsy Michigan Affiliates

Posted on August 29th 2009

The United Cerebral Palsy organization has affiliates throughout the United States.  The provide direct services to individuals and families with cerebral palsy and other disabilities.  This is a tremendous resource of information and other valuable resources.

In Michigan, the UCP affiliates are:

UCP Michigan
3401 East Saginaw, Suite 216
Lansing, MI 48912
Phone: (517) 203-1200; (800) 828-2714 (Toll Free)
Fax: (517) 203-1203
E-mail: ucp@ucpmichigan.org  Web: http://www.ucpmichigan.org

UCP of Metro Detroit
23077 Greenfield, Suite 205 Southfield, MI 48075
Phone: (248) 557-5070; (800) 827-4843
Fax: (248) 557-4456
E-mail: main@ucpdetroit.org  
Web: http://www.ucpdetroit.org

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Evaluating participation in children and young people with cerebral palsy

Posted on August 27th 2009

(Source: Developmental Medicine and Child Neurology)



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Probability of walking, wheeled mobility, and assisted mobility in children and adolescents with cerebral palsy

Posted on August 27th 2009

Aim Our aim was to describe how the probability of walking, wheeled mobility, and assisted mobility changes with environmental setting and age in children and adolescents with cerebral palsy (CP).Method The parents of a population-based sample of 642 children and adolescents (360 males, 282 females; age range 16mo[ndash]21y) reported their children’s mobility at home, school, and outdoors at 6- or 12-month intervals a mean of 5.2 times. Generalized mixed-effects analyses were used to model the probabilities.Results By age 3 years, children with motor function classified as level I according to the Gross Motor Function Classification System (GMFCS) walked in all three settings. Children/adolescents classified as level V used assisted mobility, with a small number using wheeled mobility. In …



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Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia

Posted on August 26th 2009

Interleukin-6 (IL-6) is produced by neurons, astrocytes, and microglia, and elevated levels of IL-6 within the CNS have been documented in multiple neurological disorders including Alzheimer’s disease, stroke, epilepsy, attention deficit disorder, cerebral palsy, and multiple sclerosis. Here, we sought to understand how IL-6 regulates microglial signal transduction and their immune properties. Using highly enriched cultures of neonatal murine microglia we show that IL-6 alone has direct effects on microglia as it activates STAT3 and extracellular signal-regulated kinase pathways in a time- and dose-dependent fashion and it enhances interferon-gamma (IFN[gamma])-stimulated IL-12 secretion. However, other immune properties were only weakly modulated by IL-6 when administered without the solu…



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