Kasabach-Merritt syndrome in a term neonate
A term infant presented with a large swelling of her left lower limb following birth (see figure 1). Investigations revealed a thrombocytopenia with normal haemoglobin and coagulation profile. Following review by the paediatric haematologist, a diagnosis of Kasabach–Merritt syndrome (KMS) was made and treatment with propranolol was commenced. However, the haemangioma increased in size and the baby remained dependent on multiple platelet transfusions. Propranolol was therefore replaced with intravenous vincristine. To date, the infant has received eight doses of vincristine. No vincristine-related side effects have been observed. She has remained independent of platelet transfusions, and the lesion has improved significantly since vincristine was commenced (see figure 2). KMS was firs…
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