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Neonatal Hypoxic-Ischemic Encephalopathy and Total-Body Cooling

Posted on February 28th 2010
Until recently, therapy for neonatal hypoxic ischemic encephalopathy (HIE) was nonspecific and limited. Treatment, consisting of efforts to maintain physiological stability and treat seizures with anticonvulsants, was supportive in nature and did not intervene with the basic mechanisms of hypoxic-ischemic brain injury. Although relatively uncommon (1-2 cases per 1,000 births), HIE has the potential to be devastating with residual symptoms, including cerebral palsy, developmental retardation, and epilepsy. Recent treatment studies with either total-body or selective head cooling have shown promising outcomes. Several studies strongly suggest that hypothermic therapy reduces death and neurologic disability in neonates with HIE without clinically significant complications. Selective cooling o...

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